Early B Cell Factor 3 antisense RNA 1 (EBF3-AS1)

EBF3 Antisense RNA 1 (EBF3-AS1) is a brain-expressed lncRNA with two exons, transcribed antisense to the protein-coding gene Early B Cell Factor 3 (EBF3). Its expression is upregulated in Alzheimer's disease models and human AD tissue, where it promotes neuronal apoptosis by stimulating EBF3 expression. Knockdown studies suggest that reducing EBF3-AS1 can inhibit AD-related cell death, indicating its potential as both a disease biomarker and therapeutic target. EBF3-AS1 is also of interest in the context of nervous system developmental disorders due to its regulatory influence over EBF3, a gene critical for neuronal development and migration. This molecule is primarily investigated in the context of neurodegeneration (especially Alzheimer's disease) and is not yet directly targeted by approved drugs, but therapeutic modulation is a growing area of preclinical research.

Other names

EBF3-ASEarly B cell factor 3 antisense RNAlncRNA EBF3-AS1

For potential therapies (e.g., siRNA knockdown), mechanism involves inhibiting EBF3-AS1 to reduce EBF3-mediated neuronal apoptosis and disease progression in AD