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Target intelligence / Profile preview
Early Growth Response 1 messenger RNA (EGR1 mRNA)
- Target
- EGR1 mRNA
- Molecular classification
- mRNA, Transcription factor
01
Overview
EGR1 messenger RNA (mRNA) encodes the Early Growth Response 1 (EGR1) protein, a zinc finger transcription factor involved in regulating gene expression in response to various physiological and pathological stimuli. The EGR1 gene is located on human chromosome 5. EGR1 mRNA is rapidly induced by diverse extracellular signals and plays roles in cell differentiation, mitogenesis, apoptosis, neuronal plasticity, memory formation, fibrosis regulation, and tumor suppression. It serves as a marker for cellular responses and a potential therapeutic target due to its role in cancer resistance mechanisms. It also acts as a host restriction factor inhibiting SARS-CoV‑2 replication.
- Other names
- NGFI-A mRNAKrox-24 mRNATIS8 mRNAZENK mRNA
02
Biological functions
Transcription regulationCell differentiationMitogenesisApoptosisNeuronal plasticityMemory formationFibrosis regulationTumor suppressionSignal transduction
03
Disease associations
CancerFibrotic diseasesViral infections
04
Biomarkers
Cellular response to external stimuli (hypertrophy, injury)Drug resistance in cancer
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