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Target intelligence / Profile preview
Early Growth Response Protein 1 (EGR1)
- Target
- EGR1
- Molecular classification
- Transcription factor, Cys2-His2-type zinc finger protein
01
Overview
EGR1 is a mammalian transcription factor belonging to the EGR family of Cys2-His2-type zinc finger proteins. It acts as an immediate early gene product and master regulator of transcription in response to various stimuli, regulating genes involved in cell survival, proliferation, differentiation, death, neuronal plasticity, memory formation, and fibrosis. It can act as both a tumor suppressor and promoter depending on cellular context.
- Other names
- NGFI-AKrox-24TIS8ZENKZIF268
02
Mechanism of action
Transcriptional regulation of target genes involved in cell survival, proliferation, differentiation, death, neuronal plasticity, memory formation, and fibrosis.
03
Biological functions
Transcriptional regulationCell survivalCell proliferationCell differentiationCell deathNeuronal plasticityMemory formationFibrosisDNA damage response
04
Disease associations
CancerFibrosisCardiovascular diseaseNeurodegenerative disease
05
Safety considerations
Context-dependent oncogenic propertiesPotential for tumor promotion in specific cellular contexts
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