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Target intelligence / Profile preview
Early Secreted Antigenic Target 6 kDa (ESAT-6)
- Target
- ESAT-6
- Molecular classification
- Secreted protein, Antigen, Virulence factor
01
Overview
Early secreted antigenic target 6 kDa (ESAT-6) is a small, secretory protein produced by Mycobacterium tuberculosis (Mtb). It is a potent T cell antigen and plays a central role in the pathogenesis and virulence of tuberculosis. ESAT-6 contributes significantly to Mtb’s ability to infect and persist within host cells by modulating host immune responses, disrupting phagosomal membranes, and interfering with antigen presentation. It is also a diagnostic marker and potential vaccine candidate.
- Other names
- EsxA
02
Mechanism of action
Blocking or neutralizing ESAT-6 function impairs intracellular survival of M. tuberculosis.
03
Biological functions
Immune modulationPhagosome disruptionInterference with antigen presentationBacterial virulenceCytokine induction
04
Disease associations
TuberculosisInfection
05
Safety considerations
Potential for off-target effects on immune responsesRisk of exacerbating inflammation
06
Biomarkers
IGRA-based TB tests
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