EARP and GARP complex interacting protein 1 (EIPR1)

EIPR1, also known as EARP and GARP complex interacting protein 1, is a WD40 repeat-containing scaffolding protein essential for vesicular protein trafficking in eukaryotic cells[1][2][4]. It interacts physically and functionally with the EARP (endosome-associated recycling protein) and GARP (Golgi-associated retrograde protein) complexes, supporting their stability, proper localization, and membrane association[2][1][5]. EIPR1 is crucial for the retention and sorting of cargo proteins, particularly in dense-core vesicles—specialized secretory organelles involved in regulated release of peptide hormones, growth factors, and neuropeptides[1][2][5]. EIPR1 controls the recycling of cargo molecules like the transferrin receptor and is especially important in neurons and neuroendocrine cells, impacting processes such as insulin secretion and locomotion[1][2]. The gene has also been reported as a tumor-suppressor candidate in cancer-prone genomic regions[4].

Other names

TSSC1EIPR-1Endosome-associated recycling protein-interacting proteinGolgi-associated retrograde protein-interacting proteinTumor-suppressing STF cDNA 1 proteinTumor-suppressing subchromosomal transferable fragment candidate gene 1 proteinProtein TSSC1Tumor suppressing subtransferable candidate 1Tumor-suppressing subtransferable fragment candidate gene 1

Not applicable (No drugs reported to target EIPR1 directly, so there are no mechanisms of action listed in literature.)