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Ebola Virus Glycoprotein (Zaire) (GP)
- Target
- GP
- Molecular classification
- Viral glycoprotein, Fusion protein
01
Overview
The Ebola virus glycoprotein (GP) is the sole viral protein expressed on the surface of the virion and is essential for infectivity. It mediates both attachment to host cells and catalysis of membrane fusion, making it a critical determinant of viral entry and pathogenesis. The GP is also a major target for neutralizing antibodies, vaccines, and antiviral drugs. It exists as full-length GP (GP1,2), which forms trimeric spikes, and secreted GP (sGP). The full-length GP consists of GP1 (receptor binding) and GP2 (membrane fusion) subunits. It's heavily glycosylated, contributing to immune evasion.
- Other names
- Ebola virus GP1,2Ebola virus sGPZaire ebolavirus glycoprotein
02
Mechanism of action
Neutralization of viral entry by blocking receptor binding or membrane fusion
03
Biological functions
Host cell attachmentMembrane fusionReceptor bindingImmune evasion
04
Disease associations
InfectionEbola virus disease (EVD)
05
Safety considerations
Immune evasion due to glycosylationPotential for antibody-dependent enhancement (ADE)Sequence variability between Ebola virus strains
06
Interacting drugs
KZ52
2 more in the full profile.
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