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Target intelligence / Profile preview
Ebola virus matrix protein VP40 (VP40)
- Target
- VP40
- Molecular classification
- Other, viral matrix protein
01
Overview
The Ebola virus matrix protein VP40 is a multidomain protein that plays crucial roles in the Ebola virus life cycle, including viral assembly, budding, and transcriptional regulation. It exists in different structural forms, such as a dimeric butterfly-shaped structure involved in trafficking and assembly, a hexameric structure crucial for matrix formation, and a ring structure involved in RNA binding and transcriptional control. Due to its multifunctional nature, VP40 is a potential therapeutic target for developing antiviral treatments against Ebola virus infection.
- Other names
- Ebola VP40Filovirus matrix protein
02
Mechanism of action
Interference with viral assembly and budding; Blocking transcriptional regulation
03
Biological functions
Virus assemblyViral buddingTranscriptional regulationRNA binding
04
Disease associations
Infection (Ebola virus disease)
05
Safety considerations
Associated with hemorrhagic fever, which can be fatal.
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