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Target intelligence / Profile preview
Ebolavirus Glycoprotein Base Region (GP Base Region)
- Target
- GP Base Region
- Molecular classification
- Viral protein, Glycoprotein
01
Overview
The base region of the Ebolavirus glycoprotein (GP1 subunit) is a critical structural element that stabilizes the prefusion conformation of the GP trimer. Located at the membrane-proximal end of the GP, it clamps the internal fusion loop and an α-helix from the adjacent GP2 subunit, maintaining the GP in a metastable state. This region is also a target for neutralizing antibodies like KZ52, which can disrupt viral entry.
02
Mechanism of action
Neutralizing antibodies (e.g., KZ52) block conformational changes required for membrane fusion or prevent proper assembly/stability of functional trimers.
03
Biological functions
Viral entryMembrane fusionStructural stabilization
04
Disease associations
InfectionEbola virus disease
05
Safety considerations
Targeting the base region effectively without off-target effects.
06
Interacting drugs
KZ52 (neutralizing antibody)
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