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Target intelligence / Profile preview
EBV nuclear antigen 3C (EBNA3C)
- Target
- EBNA3C
- Molecular classification
- Viral oncoprotein, Transcription factor, Transcriptional coregulator, Epigenetic regulator
01
Overview
- Other names
- EBNA-3CEBNA6EBNA-6Epstein-Barr virus nuclear antigen 3CBERF3/BERF4EBNA3C latent protein
02
Mechanism of action
Inhibition of transcriptional repression by blocking recruitment of histone deacetylases (HDACs); disruption of protein-protein interactions with host factors like RBP-Jκ or CtBP; induction of proteasomal degradation of the viral oncoprotein.
03
Biological functions
B-cell transformationCell cycle regulationApoptosis inhibitionTranscriptional activationTranscriptional repressionEpigenetic modificationImmune evasionAutophagy regulation
04
Disease associations
InfectionCancerBurkitt lymphomaHodgkin lymphomaDiffuse large B-cell lymphomaPost-transplant lymphoproliferative diseaseInfectious mononucleosisNasopharyngeal carcinomaGastric cancer
05
Safety considerations
Off-target effects of broad epigenetic or proteasome inhibitorsViral resistance through mutations in the EBNA3C geneFunctional redundancy with other EBNA3 family members (e.g., EBNA3A)Challenges in targeting latent viral proteins without affecting host cell homeostasis
06
Interacting drugs
Trichostatin A
2 more in the full profile.
07
Biomarkers
EBV DNA loadp16INK4A expression levelsBim (BCL2L11) expression levelsCD21 expression
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