Eccrine sweat gland muscarinic acetylcholine receptor (subtype 3) (null)

The eccrine sweat gland muscarinic acetylcholine receptor (subtype 3) is the primary molecular target mediating sweat production (induction of sweating) in humans. These receptors are G protein-coupled receptors located on eccrine sweat glands, which are distributed widely across the skin and play a critical role in thermoregulation. Activation of these receptors by acetylcholine, released from sympathetic postganglionic fibers, stimulates sweat secretion that cools the body through evaporation. Pharmacological modulation of these receptors (typically through antagonism) is used in the management of conditions such as hyperhidrosis (excessive sweating)[2][3][6][8].

Other names

M3 receptormuscarinic acetylcholine receptor M3CHRM3

Anticholinergics block muscarinic receptors, thereby decreasing sweat production Cholinergic agonists stimulate muscarinic receptors, increasing sweat production[3]