Echinoderm microtubule-associated protein-like 2 (EML2)

Echinoderm microtubule-associated protein-like 2 (EML2) is a cytoskeletal protein involved in the regulation of microtubule dynamics and organization. It binds tubulin, preferentially interacts with tyrosinated microtubules through a motif composed of WD40 repeats, and can track the ends of shortening microtubules, which influences microtubule stability. EML2 inhibits microtubule nucleation and growth, resulting in shorter microtubules. Dysregulation or altered expression of EML2 has been associated with several diseases, notably colon cancer (where overexpression correlates with poor prognosis), gliomas (where it is frequently methylated and considered a tumor suppressor), and nasopharyngeal carcinoma. EML2 methylation is a highly sensitive and specific biomarker for brain tissue discrimination. It is not currently considered a confirmed therapeutic target, and no drug interactions or direct mechanisms of action for therapeutic targeting are described in the literature to date.

Other names

EMAP2EMAPL2EMAP-2HuEMAP-2ELP70echinoderm MT-associated protein (EMAP)-like protein 70microtubule-associated protein like echinoderm EMAPechinoderm microtubule associated protein like 2