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Target intelligence / Profile preview
Echinoderm microtubule-associated protein-like 3 (EML3)
- Target
- EML3
- Molecular classification
- Other, Microtubule-associated protein (MAP)
01
Overview
Echinoderm microtubule-associated protein-like 3 (EML3) is a microtubule-associated protein localized to spindle microtubules and cytoplasmic microtubules. EML3 regulates mitotic spindle assembly, microtubule–kinetochore attachment, and chromosome alignment during metaphase. It does so by recruiting the Augmin complex and the γ-tubulin ring complex (γ-TuRC) to microtubules, promoting MT-based nucleation required for spindle formation and correct chromosomal segregation. Regulation of EML3 activity is cell cycle-dependent, with cyclin-dependent kinase 1 (CDK1) phosphorylation being critical for its interaction with binding partners. Knockdown of EML3 leads to defects in spindle assembly and chromosome missegregation, implicating it in diseases involving errors in cell division, such as retinitis pigmentosa. Although not currently considered a direct therapeutic target or drug receptor, EML3 has emerging significance in cell biology and disease research.
- Other names
- EMAP like 3EMAP-3FLJ35827ELP95EMAP3EMAP95echinoderm microtubule-associated protein-like 3echinoderm microtubule associated protein like 3
02
Biological functions
Microtubule bindingRegulation of mitotic spindle assemblyMitotic metaphase chromosome alignmentKinetochore–microtubule attachmentCell division (mitosis)
03
Disease associations
Retinitis pigmentosaOther (possible roles in cell division-related disease, but no direct evidence for cancer, inflammation, etc. to date)
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