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Target intelligence / Profile preview
Echinoderm microtubule-associated protein-like 4 (EML4)
- Target
- EML4
- Molecular classification
- Other (microtubule-associated protein)
01
Overview
Echinoderm microtubule-associated protein-like 4 (EML4) is a microtubule-associated protein essential for the formation and stability of microtubules and the mitotic spindle, enabling proper cell division. In cancers, especially non-small cell lung cancer, oncogenic fusions between EML4 and ALK generate the EML4-ALK fusion protein, which drives tumorigenesis by constitutively activating ALK signaling. EML4-ALK fusion-positive cancers are clinically significant due to their sensitivity to targeted ALK inhibitors.
- Other names
- C2orf2EMAPL4EMAP-4ROPP120ELP120Restrictedly overexpressed proliferation-associated proteinRopp 120EML4/ALK fusion proteinechinoderm microtubule associated protein like 4
02
Mechanism of action
Inhibition of ALK kinase activity in EML4-ALK fusion protein Disruption of downstream oncogenic signaling
03
Biological functions
Microtubule formationOrganization and stability of microtubulesFormation and stability of the mitotic spindleKinetochore-microtubule attachmentRecruitment of proteins (e.g., NUDC) for mitotic progression
04
Disease associations
Cancer (especially non-small cell lung cancer through EML4-ALK fusion)Soft tissue sarcomaSignet ring lung adenocarcinoma
05
Safety considerations
Development of resistance to ALK inhibitorsOff-target effects and toxicity related to ALK inhibitionSpecific therapeutic challenges in patients with EML4-ALK fusion-positive cancers
06
Interacting drugs
Crizotinib
4 more in the full profile.
07
Biomarkers
EML4-ALK fusion is a predictive biomarker for ALK inhibitor therapy in lung cancer
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