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Target intelligence / Profile preview
Ecotropic viral integration site 5-like protein (EVI5L)
- Target
- EVI5L
- Molecular classification
- Enzyme (GTPase-activating protein; GAP), TBC domain-containing protein, Other (small GTPase binding)
01
Overview
Ecotropic viral integration site 5-like protein (EVI5L) is a TBC domain–containing GTPase-activating protein (GAP) that modulates Rab GTPase activity, notably Rab10 and Rab23, thereby controlling primary cilium formation and membrane trafficking[1][2][3][4][8]. It is primarily located on intracellular membranes and is involved in negative regulation of ciliary assembly, intracellular protein transport, and positive regulation of GTPase activity[1][4][8]. EVI5L also interacts with several protein complexes, and variants or non-coding RNAs from its locus are associated with several physiological and pathological states such as urolithiasis and X-linked intellectual disability, though direct disease causality in humans is not strongly established[1][2][3].
- Other names
- EVI5LEVI5-like proteinEcotropic viral integration site 5-like proteinEpididymis secretory sperm-binding protein
02
Mechanism of action
No mechanism of action is established for drugs targeting EVI5L directly as it is not a validated drug target[2][4].
03
Biological functions
Negative regulation of cilium assemblyPositive regulation of GTPase activityIntracellular protein transportCell cycle progression (potentially, based on homology to EVI5)Membrane traffickingCell differentiation (shown in mouse studies)
04
Disease associations
Non-syndromic X-linked intellectual disabilityAlport syndromeUrolithiasis (urinary stone disease, via lncRNA from locus)Mammary epithelial cell regulation (via non-coding RNAs)Other (broad cell cycle–related changes suggested, but not directly validated in human disease)
05
Biomarkers
lnc–EVI5L–1 (Long non-coding RNA from the EVI5L locus, implicated in urolithiasis)Activity and expression changes in certain cell types (e.g., mammary epithelial cells)
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