Ecotropic viral integration site 5 protein homolog (EVI5)

Ecotropic viral integration site 5 protein homolog (EVI5) is a human protein encoded by the EVI5 gene. It functions as a GTPase-activating protein (GAP) for Rab small G-proteins—especially Rab11—regulating vesicular trafficking and cell cycle progression by stabilizing key proteins such as FBXO5 and promoting cyclin-A accumulation during interphase[2][7][11]. The protein contains a TBC (TRE2/BUB/CDC16 homology) domain and acts as a centrosomal protein, redistributing during mitosis to the midbody, and is essential for proper cytokinesis (cell division)[2][11]. Disruption of EVI5 leads to multinucleate cells and has been linked to the pathogenesis of neuroblastoma, with a specific role as a genetic marker of disease onset and progression[2][3][4]. While not considered a classical drug target currently, it represents a critical regulator of cell proliferation and organogenesis, especially in experimental or developmental contexts. As such, its modulation could be therapeutically relevant for proliferative or developmental diseases, although no compounds have advanced to clinical targeting as of September 2025.

Other names

Neuroblastoma stage 4S gene proteinNB4SEVI-5dJ846D11.1Ecotropic viral integration site 5 protein homologNeuroblastoma stage 4S gene

Not applicable; no drugs known to directly target EVI5. Mechanism, if targeted, would likely involve inhibition or modulation of GTPase-activating function or disruption of cell cycle regulation.