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Ecto-NADH oxidase disulfide-thiol exchanger 2 (ENOX2)
- Target
- ENOX2
- Molecular classification
- Enzyme, Ecto-nicotinamide adenine dinucleotide oxidase
01
Overview
Tumor-associated NADH oxidase (tNOX), also known as ENOX2, is a growth-related protein predominantly expressed on the surface of cancer cells. It catalyzes the oxidation of NADH to NAD+, regulating the cellular NAD+/NADH ratio, which is crucial for various metabolic pathways, including cell cycle progression and apoptosis. tNOX supports tumor cell proliferation by maintaining redox balance favorable for rapid growth. It serves as a potential biomarker for cancer detection/progression monitoring and represents an attractive target for anti-cancer therapies.
- Other names
- Tumor-associated NADH oxidasetNOX
02
Mechanism of action
Inhibition of tNOX activity, leading to decreased NAD+/NADH ratio, increased p53 acetylation, and induction of apoptosis.
03
Biological functions
Redox regulationCell proliferationApoptosis modulationNADH oxidation
04
Disease associations
Cancer
05
Safety considerations
Selective cytotoxicity against tumors while sparing normal tissue is crucial.
06
Interacting drugs
Oxaliplatin
07
Biomarkers
tNOX serum levels for cancer detection/progression monitoring
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