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Target intelligence / Profile preview
Tumor-associated NADH oxidase (ENOX2)
- Target
- ENOX2
- Molecular classification
- Enzyme, Oxidase, Protein disulfide isomerase
01
Overview
Tumor-associated NADH oxidase (ENOX2), also known as ecto-NOX disulfide-thiol exchanger 2 or tNOX, is a dimeric protein containing four copper atoms per dimer. It functions as a terminal oxidase in plasma membrane electron transport, catalyzing the oxidation of NADH to NAD+. ENOX2 activity oscillates with a period of about 24 minutes under normal conditions. The tumor-specific splice variant tNOX is found on the surface of many human cancers but not on most normal cells and is constitutively active. It is a potential pan-cancer biomarker and therapeutic target.
- Other names
- Ecto-NOX disulfide-thiol exchanger 2tNOX
02
Mechanism of action
Selective inhibition of tNOX activity in cancer cells, leading to anti-cancer effects.
03
Biological functions
Oxidation of NADH/NAD(P)HProtein disulfide-thiol exchangeCell growth regulationBiological clock regulation
04
Disease associations
Cancer
05
Safety considerations
Selectivity for tNOX over native forms (CNOX/ENOX1, arNOX) is crucial to avoid off-target effects.
06
Interacting drugs
Phenoxodiol
4 more in the full profile.
07
Biomarkers
tNOX/ENOX2 expression in tumor tissuetNOX/ENOX2 levels in serum
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