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Ecto-nucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
- Target
- ENTPD1
- Molecular classification
- Enzyme, Ectonucleotidase
01
Overview
ENTPD1/CD39 is a cell surface enzyme that catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), such as ATP and ADP, to their corresponding monophosphates (AMP). It plays a critical role in modulating immune cell chemotaxis, regulating vascular endothelial function, preventing desensitization of platelet receptors, and generating extracellular adenosine.
- Other names
- CD39NTPDase1ATPDaseSPG64
02
Mechanism of action
Hydrolyzes extracellular ATP and ADP to AMP, ultimately leading to adenosine production.
03
Biological functions
Hydrolysis of extracellular NDPs/NTPsRegulation of purinergic signalingImmune cell migrationVascular homeostasisModulation of inflammation
04
Disease associations
Cardiovascular diseaseInflammationIschemic cardiomyopathyThromboregulation
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