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Ectodysplasin A Receptor
- Molecular classification
- Receptor, Tumor necrosis factor receptor superfamily
01
Overview
The ectodysplasin A receptor (EDAR) is a cell surface protein that plays a crucial role in embryonic development, particularly in the formation of ectodermal tissues such as skin, hair, nails, teeth, and sweat glands. Upon binding with its ligand (EDA-A1), EDAR recruits EDARADD, activating NF-kappaB, Wnt/β-catenin, JNK, BMP/Smad, and FGF pathways.
- Other names
- DLectodysplasin 1, anhidrotic receptorectodysplasin A1 isoform receptorED1RED3ED5EDA-A1REDA1REDA3
02
Mechanism of action
EDA-A1 ligand binds to extracellular domain of EDAR, recruits intracellular adaptor protein EDARADD via death domain, activates NF-kappaB & other developmental signaling cascades, regulates formation/maturation/division/growth of cells forming skin appendages etc.
03
Biological functions
Signal transductionCell proliferationCell growthCell maturationMorphogenesis of hair folliclesMorphogenesis of sweat glandsMorphogenesis of teeth
04
Disease associations
Hypohidrotic ectodermal dysplasiaNonsyndromic tooth agenesisTumor pathogenesis
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