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Target intelligence / Profile preview
Ectonucleoside triphosphate diphosphohydrolase 1 (CD39)
- Target
- CD39
- Molecular classification
- Enzyme, Ectonucleotidase
01
Overview
Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) is a cell surface enzyme that hydrolyzes extracellular ATP and ADP to AMP. It plays a crucial role in regulating purinergic signaling, inhibiting platelet aggregation, and modulating inflammation and fibrosis, particularly in the cardiovascular system.
- Other names
- ENTPD1NTPDase-1ATPDaseSPG64
02
Mechanism of action
Hydrolyzes γ- and β-phosphate residues of nucleoside tri- and diphosphates (e.g., ATP, ADP, UTP, UDP) to their corresponding monophosphates (e.g., AMP).
03
Biological functions
Hydrolysis of extracellular ATP/ADP/UTP/UDPRegulation of purinergic signalingInhibition of platelet aggregationModulation of inflammationModulation of fibrosisVascular homeostasisThromboregulation
04
Disease associations
Cardiovascular diseaseMyocardial infarctionThrombosisInflammationImmune dysregulation
05
Safety considerations
Lack of highly selective inhibitors
06
Interacting drugs
DIDS
5 more in the full profile.
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