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Target intelligence / Profile preview
Ectonucleoside triphosphate diphosphohydrolase 3 (CD39L3)
- Target
- CD39L3
- Molecular classification
- Enzyme, Hydrolase, Ectonucleotidase, Integral membrane protein
01
Overview
Ectonucleoside triphosphate diphosphohydrolase 3 (CD39L3) is an ectonucleotidase that hydrolyzes extracellular nucleotides, particularly ATP and ADP, regulating purinergic signaling. It is involved in various physiological processes, including feeding and sleep regulation in the brain. CD39L3 is highly expressed in the brain, pancreas, spleen, and prostate. Alterations in CD39L3 expression have been observed in Crohn's disease patients, suggesting a potential role in inflammatory bowel diseases.
- Other names
- NTPDase-3HB6
02
Biological functions
Regulation of extracellular nucleotide levelsPurinergic signalingRegulation of feeding behaviorRegulation of sleep behavior
03
Disease associations
Inflammatory bowel diseasesCrohn's disease
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