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EDB-Fibronectin Domain (None)
- Target
- None
- Molecular classification
- Extracellular matrix protein domain, Fibronectin type III repeat
01
Overview
The EDB-fibronectin domain (EDB-FN) is a 91-amino acid sequence inserted into the fibronectin protein via alternative splicing. It is highly expressed during embryonic development and re-expressed in pathological conditions such as cancer and angiogenesis. EDB-FN promotes cell adhesion, migration, and angiogenesis, contributing to tumor progression. Due to its restricted expression pattern, it serves as a cancer biomarker and therapeutic target for drug delivery and immunotherapy.
- Other names
- Extra Domain B of FibronectinFN-EDBED-B
02
Mechanism of action
Targeted delivery of cytotoxic agents; Tumor vasculature targeting via immunotherapy; Disruption of ECM integrity and angiogenesis inhibition
03
Biological functions
Cell adhesionCell migrationAngiogenesisExtracellular matrix assemblyTumor progression
04
Disease associations
CancerAngiogenesisTissue remodeling
05
Safety considerations
Off-target effects in tissues with transient EDB-FN expressionLimited antigen accessibility due to ECM embeddingPotential for immune-related adverse events with immunotherapy
06
Interacting drugs
Antibody-drug conjugates targeting EDB
2 more in the full profile.
07
Biomarkers
EDB-FN expression in tumor tissueEDB-FN expression in tumor vasculature
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