EF-hand calcium-binding domain-containing protein 11 (EFCAB11)

EF-hand calcium-binding domain-containing protein 11 is a human protein consisting of an EF-hand motif, a helix–loop–helix structure that facilitates calcium ion binding[2][6]. Proteins with EF-hand domains commonly serve as calcium sensors and mediators of calcium-dependent conformational changes, but for EFCAB11 specifically, detailed functional roles are still not fully characterized[1][3]. It is predicted to be involved in microtubule cytoskeleton organization and enzyme regulation, and localized within the cytoplasm[5]. The EF-hand motif is typical of proteins mediating responses to changes in cellular calcium levels, although for EFCAB11, no definitive evidence supports a receptor, enzyme, or transporter role[1][3]. No approved drugs, therapeutic antibodies, or known biomarkers are associated with EFCAB11 as of current data.\n\nEFCAB11 is not currently recognized as a therapeutic target; there is no evidence it functions as a receptor, enzyme, transporter, or known disease driver. Its main significance lies in its predicted calcium-binding ability and potential, yet not established, involvement in cytoskeletal regulation[1][3][5]. There is no indication of incorrect naming or missed information beyond the absence of direct disease or pharmacological relevance.

Other names

EF-hand calcium-binding domain 11EFCAB11C14orf143EF-hand domain-containing protein C14orf143EF-hand calcium-binding domain-containing protein 11