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Target intelligence / Profile preview
Eg5 Kinesin-Related Motor Protein (Eg5)
- Target
- Eg5
- Molecular classification
- Motor Protein, Kinesin Superfamily
01
Overview
Eg5, also known as kinesin-5 or KIF11, is a plus-end directed motor protein essential for mitosis. It forms a homotetrameric complex that cross-links anti-parallel microtubules within the mitotic spindle, driving their separation to establish and maintain spindle bipolarity. Due to its critical role in cell division, Eg5 is a target for anticancer therapies, with small-molecule inhibitors being developed to disrupt spindle formation and induce apoptosis in rapidly dividing cancer cells. Emerging evidence suggests it may have non-canonical functions in interphase as well.
- Other names
- KIF11Kinesin-5Kinesin Spindle ProteinKSPBimCN-2
02
Mechanism of action
Inhibition of Eg5 ATPase activity, leading to mitotic arrest and apoptosis.
03
Biological functions
MitosisSpindle AssemblyCentrosome SeparationChromosome PositioningMicrotubule CrosslinkingPolypeptide Synthesis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to the conservation of kinesin motor domains.Toxicity associated with mitotic disruption.
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