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EGFLAM antisense RNA 1 (EGFLAM-AS1)
- Target
- EGFLAM-AS1
- Molecular classification
- Long noncoding RNA, Antisense RNA, Non-protein coding RNA
01
Overview
EGFLAM antisense RNA 1 (EGFLAM-AS1) is a long noncoding RNA (lncRNA) derived from the antisense strand of the EGFLAM gene locus. It is non-protein coding and has been identified as significantly downregulated in gastric cancer tissue. Its reduced expression may reflect tumor presence or progression, making it a candidate biomarker for gastric cancer diagnosis or prognosis. There is no clear evidence that EGFLAM-AS1 is a direct therapeutic target, though it may regulate biological processes—possibly influencing gene expression, cell proliferation, or cell adhesion through antisense or epigenetic mechanisms[1].
- Other names
- lncRNA-LOWEGCTD-2108O9.1lncRNA low expressed in gastric cancerEGFLAM antisense RNA 1 (non-protein coding)
02
Mechanism of action
Not applicable for drugs, as it is not directly targeted by therapeutics. Biological mechanism is likely regulation of gene expression via antisense transcript effects or epigenetic influence.
03
Biological functions
Regulation of gene expressionPossible influence on cell proliferationPossible role in cell adhesionAssociated with cancer progression
04
Disease associations
Cancer (primarily gastric cancer, where low expression is observed)Potential biomarker for diagnosis or prognosis in gastric cancer
05
Biomarkers
Low expression in gastric cancer tissue may serve as a biomarker for diagnosis or prognosis[1]
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