EGFR long non-coding downstream RNA (ELDR)

EGFR long non-coding downstream RNA (ELDR), also known as Fabl or LINC01156, is a recently characterized long non-coding RNA (lncRNA) found immediately downstream of the epidermal growth factor receptor (EGFR) gene on chromosome 7p11.2, transcribed from the opposite DNA strand. ELDR is not protein-coding and acts through multiple mechanisms including interaction with proteins (such as ILF3), inhibition of microRNA (miR-7)-mediated EGFR destabilization, and stabilization of Cyclin E1 transcripts. ELDR is highly expressed in neural stem cells and is associated with neural differentiation and brain development in animal models. In humans, it is most highly expressed in testis, and is present at lower levels in multiple tissues. It is consistently upregulated in head and neck cancers, glioma, and triple-negative breast cancer, acting as an oncogenic lncRNA that promotes proliferation, cell cycle progression, and tumorigenesis. Suppression of ELDR (for example, by siRNA) can arrest tumor growth in preclinical models, suggesting its therapeutic potential. However, there are currently no approved therapies that directly target ELDR, and its clinical significance as a drug target is still under investigation[1][3].

Other names

FablLINC01156

Interferes with miRNA-mediated degradation of EGFR (notably by inhibiting miR-7), interacts with ILF3 to stabilize Cyclin E1 mRNA and promote cell cycle progression, contributes to EGFR pathway stabilization in cancer