EH domain-containing protein 2 (EHD2)

EH domain-containing protein 2 (EHD2) is a membrane-associated, dynamin-related ATPase that plays a critical role in stabilizing caveolae—plasma membrane invaginations involved in lipid regulation and signaling—by restricting their scission and endocytosis[1][3]. EHD2 cycles between inactive (cytosolic) and active (membrane-bound) states via ATP-dependent conformational changes, oligomerizing at caveolar necks to stabilize membrane curvature and dynamics[1][3]. It associates with the actin cytoskeleton, influences the structure and transport of membranes, and participates in endocytic pathways, including clathrin-mediated endocytosis[4]. EHD2 is also capable of translocating to the nucleus, where it acts as a transcriptional corepressor[2]. It is crucial for the integrity of plasma membranes, proper insulin signaling, lipid handling, and glucose uptake, and its dysregulation has been implicated in cancer, metabolic disorders (diabetes, obesity), cardiovascular disease, and certain myopathies[2][3][4]. While EHD2 is recognized as a potential therapeutic target, currently no approved drugs or clinical biomarkers are specifically directed at EHD2[2][3][4].

Other names

EHD2PAST2PAST homolog 2EH domain containing 2