EH domain-containing protein 4 (EHD4)

EH domain-containing protein 4 (EHD4) is a member of the dynamin-related ATPase family involved in cellular membrane trafficking, endocytic recycling, and membrane remodeling in multiple tissues[2][3][4][6][7]. EHD4 binds ATP and associates with lipid membranes, oligomerizing and inducing membrane tubulation to facilitate early endosomal transport[2][4]. In neuronal cells, EHD4 is implicated in the internalization of neurotrophic receptors (TrkA, TrkB) and interacts with proteins such as EHD1, NUMB, PACSIN2, and MICALL1 in the control of membrane protein trafficking[6]. EHD4 is expressed in various tissues, prevalent in heart and detectable in brain, fibroblasts, and cartilage, with functional redundancy alongside other EHD family members[1][6][7]. Disease associations include several cancers and developmental abnormalities[3][6]. No drugs are currently clinically known to directly target EHD4.

Other names

EHD4PAST4HCA10HCA11FKSG7Hepatocellular carcinoma-associated protein 10/11PAST homolog 4EH domain-containing protein 4Ortholog of rat pincher

Drugs targeting EHD4 would likely modulate endocytic trafficking, membrane remodeling, or receptor internalization pathways; however, no specific drugs are known[3][6].