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Target intelligence / Profile preview
Eicosanoid Pathway Enzymes (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Oxidase, Monooxygenase
01
Overview
Eicosanoid pathway enzymes are a group of enzymes responsible for the biosynthesis of eicosanoids, which are bioactive lipid mediators derived from the oxidation of polyunsaturated fatty acids (PUFAs), primarily arachidonic acid. Eicosanoids play crucial roles in inflammation, vascular homeostasis, pain perception, immune responses, and various physiological and pathological processes. The main enzyme families involved are Cyclooxygenases (COX), Lipoxygenases (LOX), and Cytochrome P450 Monooxygenases (CYP).
- Other names
- Cyclooxygenases (COX)Lipoxygenases (LOX)Cytochrome P450 Monooxygenases (CYP)COX-1COX-25-LOX12-LOX15-LOXCYP2CCYP2JCYP4ACYP4F
02
Mechanism of action
Enzyme inhibition
03
Biological functions
Eicosanoid biosynthesisInflammation modulationRegulation of blood pressureVascular tone regulationPlatelet aggregationImmune cell recruitmentAutocrine signalingParacrine signaling
04
Disease associations
InflammationCardiovascular diseasePainAsthmaAllergic conditionsCancerChronic disease
05
Safety considerations
Gastrointestinal issues (NSAIDs)Cardiovascular risks (COX-2 inhibitors)Potential for off-target effects due to overlapping substrate specificities
06
Interacting drugs
Nonsteroidal anti-inflammatory drugs (NSAIDs)
1 more in the full profile.
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