Eicosanoid pathway modulation via eicosapentaenoic acid incorporation into cell membranes (None)

Eicosapentaenoic acid (EPA) is a long-chain omega-3 polyunsaturated fatty acid (PUFA) that modulates the eicosanoid pathway when incorporated into cell membrane phospholipids. This occurs primarily by altering the substrate availability for eicosanoid biosynthesis, displacing arachidonic acid, and affecting membrane properties that influence protein function and signaling. The incorporation of EPA leads to a shift in the balance from AA-derived pro-inflammatory mediators toward less inflammatory mediators, reducing inflammation and providing cardiovascular benefits. EPA can also impact cholesterol efflux, depending on cell type and metabolic state.

Other names

EPA incorporation into cell membranesOmega-3 PUFA incorporationEicosapentaenoic acid (EPA)EPA-mediated eicosanoid modulation

EPA is incorporated into cellular phospholipids, displacing arachidonic acid (AA), and reducing the production of pro-inflammatory eicosanoids. It also modulates membrane properties, affecting enzyme and receptor activity.