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Arachidonic Acid Metabolism Enzymes (AA Metabolism Enzymes)
- Target
- AA Metabolism Enzymes
- Molecular classification
- Enzyme, Phospholipase, Cyclooxygenase, Lipoxygenase, Cytochrome P450 Monooxygenase
01
Overview
Arachidonic acid metabolism enzymes are a group of proteins responsible for the liberation and subsequent conversion of arachidonic acid into bioactive lipid mediators. These metabolites play crucial roles in inflammation, cell proliferation, differentiation, apoptosis, and homeostasis. Key enzyme families include phospholipases, cyclooxygenases, lipoxygenases, and cytochrome P450 monooxygenases. Products, termed eicosanoids, act as local hormones or signaling molecules. Inhibitors of these enzymes are used therapeutically for various diseases.
- Other names
- Eicosanoid Synthesis EnzymesArachidonate Cascade EnzymesProstaglandin SynthasesLeukotriene SynthasesLipoxygenase EnzymesCyclooxygenase EnzymesPhospholipase EnzymesCytochrome P450 Epoxygenases
02
Mechanism of action
Enzyme inhibition; Receptor antagonism; Modulation of enzyme activity
03
Biological functions
Arachidonic acid metabolismEicosanoid synthesisInflammationVascular tone regulationImmune response modulationCell proliferationApoptosisPlatelet aggregationVasodilation
04
Disease associations
InflammationCardiovascular diseaseCancerAsthmaAllergyDiabetesObesityFibrosisNeuroinflammation
05
Safety considerations
Gastrointestinal side effects (NSAIDs)Cardiovascular risks (COX-2 inhibitors)Liver toxicity (Leukotriene inhibitors)Drug interactions (CYP inhibitors)
06
Interacting drugs
NSAIDs (e.g., Ibuprofen, Aspirin, Celecoxib)
3 more in the full profile.
07
Biomarkers
Prostaglandin levelsLeukotriene levelsEET levelsHETE levelsCOX-2 expression5-LOX expression
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