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Target intelligence / Profile preview
EIF1AX antisense RNA 1 (EIF1AX-AS1)
- Target
- EIF1AX-AS1
- Molecular classification
- Long noncoding RNA, Antisense RNA
01
Overview
EIF1AX antisense RNA 1 (EIF1AX-AS1) is a long noncoding RNA classified as an antisense transcript to the EIF1AX gene, predominantly localized in the cytoplasm of endometrial cancer cells[1]. EIF1AX-AS1 is downregulated in endometrial carcinoma tissues and acts as a tumor suppressor, inhibiting cell proliferation and promoting apoptosis by destabilizing EIF1AX mRNA through binding to poly C binding protein 1 (PCBP1)[1][5]. This regulatory axis affects c-Myc translation and is implicated in tumor growth, suggesting EIF1AX-AS1 as a potential prognostic biomarker and candidate for therapeutic exploration in endometrial cancer[1][5]. There are currently no approved drugs or direct pharmacological modulators targeting EIF1AX-AS1 itself.
- Other names
- EIF1AX antisense RNA 1 (non-protein coding)EIF1AX-AS1
02
Biological functions
Regulation of mRNA stabilityNegative regulation of cell proliferationPromotion of apoptosis
03
Disease associations
Cancer (notably endometrial cancer)
04
Biomarkers
Potential biomarker for prognosis in endometrial cancer
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