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Target intelligence / Profile preview
EIF2AK3 antisense RNA 1 (EIF2AK3-AS1)
- Target
- EIF2AK3-AS1
- Molecular classification
- Other (long noncoding RNA, antisense RNA)
01
Overview
EIF2AK3 antisense RNA 1 (EIF2AK3-AS1) is an antisense long noncoding RNA transcribed from the EIF2AK3 locus on chromosome 2, opposite the sense (protein-coding) EIF2AK3 gene. Antisense RNAs generally function as regulators of gene expression, often through formation of RNA:RNA duplexes with their sense counterparts, chromatin modification, or by interfering with transcription. Specific functions, disease associations, and drug interactions for EIF2AK3-AS1 have not been well defined in the literature. However, antisense lncRNAs are broadly implicated in the epigenetic regulation of neighboring protein-coding genes and may influence cellular response to stress or cancer-linked pathways through regulation of their target genes.
- Other names
- EIF2AK3-AS1
02
Mechanism of action
Not applicable; antisense lncRNAs generally act by RNA-mediated modification of gene expression in cis or trans
03
Biological functions
Regulation of gene expression (through antisense transcription, chromatin remodeling, transcriptional interference)
04
Disease associations
Other (Possible involvement in cancer or other diseases via epigenetic regulation; not documented specifically for EIF2AK3-AS1)
05
Safety considerations
None documented; therapeutic targeting of lncRNAs in general may have off-target and epigenetic effects
06
Interacting drugs
None known specifically for EIF2AK3-AS1
07
Biomarkers
None known specifically for EIF2AK3-AS1
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