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Target intelligence / Profile preview
EIF5 antisense RNA 1 (EIF5-AS1)
- Target
- EIF5-AS1
- Molecular classification
- Other, Long non-coding RNA, lncRNA
01
Overview
EIF5 divergent transcript (EIF5-DT), also known as EIF5-AS1 or LINC00346, is a human long non-coding RNA transcribed divergently from the EIF5 gene locus. It does not encode a protein but has been observed to regulate the expression of neighboring or overlapping protein-coding genes and is frequently implicated in tumor development, progression, and prognosis across multiple cancer types. As a regulatory RNA, EIF5-DT may modulate gene expression through interactions with chromatin, microRNAs, or mRNA stability. Overexpression or dysregulation of EIF5-DT has been associated with several human cancers, and higher levels may correlate with poor prognosis. However, it is not considered a direct therapeutic target such as a receptor or enzyme, though it may have value as a biomarker for cancer diagnosis or prognosis.
- Other names
- EIF5-DTEIF5 antisense RNA 1LINC00346EIF5-AS1 lncRNA
02
Biological functions
Regulation of gene expressionCell proliferationCancer progressionModulation of apoptosisOther
03
Disease associations
CancerOther
04
Biomarkers
Overexpression has been proposed as a cancer biomarker in several cancers (such as colorectal, gastric, and hepatocellular carcinoma)
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