Target intelligence / Profile preview

Elastin (ELN)

Target: ELN
Molecular classification: Extracellular matrix protein

Overview

Elastin is a highly elastic, resilient protein that is a major component of the extracellular matrix (ECM) in vertebrate tissues. It provides stretchiness and the ability to recoil, making it essential for tissues that undergo repeated deformation such as skin, lungs, blood vessels, and certain ligaments. It consists of cross-linked tropoelastin monomers and is encoded by the ELN gene. Defects or loss of elastin can lead to tissue laxity/sagging skin or serious vascular/lung diseases.

Biological functions

Provides extensibility and elastic recoil to soft tissuesStructural component of extracellular matrix

Disease associations

Cutis laxaEmphysemaVascular diseasesSkin agingGenetic disorders affecting ELN gene function

Safety considerations

Degradation increases with aging or disease statesDefects or loss of elastin can lead to tissue laxity/sagging skin or serious vascular/lung diseases

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