Electron transfer flavoprotein beta subunit lysine methyltransferase (ETFBKMT)

Electron transfer flavoprotein beta subunit lysine methyltransferase (ETFBKMT, also known as METTL20) is a mitochondrial enzyme that specifically trimethylates lysine residues on the beta subunit of electron transfer flavoprotein (ETFB). This posttranslational modification can negatively regulate ETFB’s function in electron transfer from acyl-CoA dehydrogenases to the respiratory chain, thus modulating mitochondrial fatty acid oxidation and energy metabolism. Genetic variants in ETFBKMT are associated with metabolic disorders such as multiple acyl-CoA dehydrogenase deficiency, which impacts mitochondrial fatty acid and amino acid catabolism. The protein is also involved in pathways related to protein methylation and has a paralog, HEMK1. Currently, no direct drugs are approved or known to target ETFBKMT, and there are no established biomarkers or safety issues specifically associated with this enzyme in clinical contexts.

Other names

METTL20C12orf72ETKMTProtein N-lysine methyltransferase METTL20Methyltransferase-like protein 20ETFB lysine methyltransferaseDKFZp451L235MGC50559

Catalytic methylation of lysine residues on ETFB, regulating its function in the mitochondrial electron transfer chain