Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Eleven-nineteen Leukemia Protein (None)
- Target
- None
- Molecular classification
- Transcription factor, Chromatin regulator, Histone modification
01
Overview
ENL, also known as MLLT1, is a nuclear protein that plays a crucial role in chromatin regulation and transcriptional elongation. It functions as a histone acetylation reader, recognizing acetylated lysine residues on histone H3 via its YEATS domain. ENL is also a component of the super elongation complex (SEC), facilitating RNA polymerase II-mediated transcription. Aberrant ENL activity, particularly through MLL–ENL fusion in acute leukemias, drives oncogenic gene expression. The YEATS domain is a therapeutic target, with small-molecule inhibitors under investigation for treating AML.
- Other names
- MLLT1LTG19YEATS1Super Elongation Complex Subunit
02
Mechanism of action
YEATS domain inhibition
03
Biological functions
Chromatin remodelingRegulation of proto-oncogenesTranscriptional elongation
04
Disease associations
CancerAcute myeloid leukemia
Beyond the preview
Go deeper on Eleven-nineteen Leukemia Protein (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Eleven-nineteen Leukemia Protein (None).