ELL-associated factor 1 (EAF1)

ELL-associated factor 1 (EAF1) is a transcription elongation factor that partners with the RNA polymerase II elongation factor ELL to modulate gene expression. It regulates transcription elongation, cellular proliferation, differentiation, and hormone signaling by forming multiprotein complexes and interacting with critical transcriptional machinery. EAF1 acts as a tumor suppressor in prostate epithelial cells, and its disruption is implicated in the development of acute myeloid leukemia via oncogenic fusion proteins (MLL-ELL and MLL-EAF1). EAF1 also plays a role in embryogenesis, cell fate decision, and erythroid differentiation through c-Myb and Wnt signaling pathways

Other names

EAF1ELL-associated factor 1ELL (eleven nineteen lysine-rich leukemia gene)-associated factor 1

No drugs directly target EAF1. In the context of disease, targeting EAF1 could theoretically impact transcriptional regulation, oncogenic fusion proteins, or cell differentiation—but mechanisms remain experimental or unknown.