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Target intelligence / Profile preview
Elongation Factor 1 Alpha (EF-1A)
- Target
- EF-1A
- Molecular classification
- Translation factor, GTPase
01
Overview
Elongation factor 1 alpha (EF-1A), also known as eukaryotic translation elongation factor 1 alpha (eEF1A), is a highly conserved and essential protein in eukaryotes. It plays a central role in protein synthesis by mediating the delivery of aminoacyl-tRNAs to the A-site of ribosomes during the elongation phase of translation. Beyond this canonical function, EF-1A also participates in cytoskeleton organization, protein degradation, RNA stabilization, transcription regulation, and stress response. Altered EF-1A expression/function has been implicated in diseases like Felty's syndrome, viral infections, and neurodegenerative disorders.
- Other names
- eEF1Aeukaryotic translation elongation factor 1 alpha
02
Mechanism of action
N/A
03
Biological functions
Translation ElongationRegulation of cytoskeleton organizationProtein degradationRNA stabilizationRegulation of transcriptionHeat shock protein inductionCoactivator activity
04
Disease associations
Felty's syndromeViral InfectionNeurological DisordersEpilepsy syndromesNeurodegeneration (Alzheimer’s/Parkinson’s)
05
Safety considerations
Altered expression or function can impact translational fidelity/efficiency.Inhibition could have broad effects on cellular protein synthesis.
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