Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Elongation factor 2 (EF-2)
- Target
- EF-2
- Molecular classification
- Translation elongation factor, GTP-binding protein, Enzyme substrate (for ADP-ribosyltransferases)
01
Overview
Elongation factor 2 (EF-2) is a eukaryotic GTP-binding translation elongation factor that catalyzes the translocation step during protein synthesis, moving the mRNA and ribosome after peptide bond formation. It is an essential component of the protein synthesis machinery. Pseudomonas exotoxin A specifically inactivates EF-2 through ADP-ribosylation, transferring the ADP-ribose moiety from NAD+ to a histidine residue (diphthamide) in EF-2, thereby blocking translation and causing cell death. This mechanism is similar to that of diphtheria toxin.
- Other names
- Elongation factor 2EF-2EEF2
02
Mechanism of action
ADP-ribosylation of EF-2 by Pseudomonas exotoxin A (and diphtheria toxin), which inactivates EF-2 and stops translation in eukaryotic cells
03
Biological functions
Protein synthesis/translation elongationmRNA translation
04
Disease associations
Infection (targeted by bacterial toxins, notably in Pseudomonas and diphtheria infections)Cell death (by inhibition of protein synthesis)
05
Safety considerations
Life-threatening protein synthesis inhibition if EF-2 is inactivated by exotoxins
06
Interacting drugs
Not directly targeted by clinical drugs, but inactivated by bacterial toxins such as Pseudomonas exotoxin A and diphtheria toxin
07
Biomarkers
Essentially none established for clinical drug selection; EF-2 activity may be a research biomarker for toxin exposure
Beyond the preview
Go deeper on Elongation factor 2 (EF-2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Elongation factor 2 (EF-2).