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Elongation Factor G (EF-G)

Target: EF-G
Molecular classification: Guanosine triphosphatase (GTPase), Enzyme, Elongation Factor

Overview

Elongation factor G (EF-G) is a prokaryotic elongation factor and a member of the GTPase superfamily. It plays an essential role in protein synthesis by catalyzing the translocation step during mRNA translation on the ribosome. It also plays a key role in ribosome recycling. It is a target for the antibiotic fusidic acid.

Other names: Translocase

Mechanism of action

Fusidic acid inhibits EF-G by trapping it on the ribosome after tRNA translocation but before it can dissociate, blocking further rounds of translation or recycling.

Biological functions

tRNA/mRNA translocationPost-translational recyclingProtein synthesis

Disease associations

Infection (bacterial)Other

Safety considerations

Antibiotic resistance

Interacting drugs

Fusidic acid

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