Elongation factor-like GTPase 1 (EFL1)

Elongation factor-like GTPase 1 (EFL1) is an essential cytosolic protein that catalyzes GTP hydrolysis and is crucial for the final maturation step of the 60S ribosomal subunit. Working in concert with the SBDS protein, EFL1 mediates the release of the ribosome anti-association factor eIF6 from pre-60S subunits, enabling functional 80S ribosome assembly and protein synthesis. Loss-of-function mutations in EFL1 result in Shwachman-Diamond syndrome, characterized by bone marrow failure, pancreatic insufficiency, and increased risk of hematologic malignancy. EFL1 is highly conserved across eukaryotes, belongs to the ribosome biogenesis/assembly protein family, and plays no direct known role in drug pharmacology or as a drug target as of 2025[2][3][4][5].

Other names

EFTUD1FAM42ARIA1HsT19294FLJ13119Protein FAM42AElongation factor Tu GTP-binding domain-containing protein 1Ribosome assembly 1 homolog (yeast), SDS2

Not applicable (no drugs known targeting EFL1 specifically). Theoretically, inhibition or modulation of EFL1 would impair ribosome assembly and protein synthesis, which may be undesirable in most contexts due to essential cellular functions[2].