Elongator acetyltransferase complex subunit 2 (ELP2)

Elongator acetyltransferase complex subunit 2 (ELP2) is a highly conserved, non-catalytic scaffold protein essential for assembling and maintaining the Elongator complex, which regulates transcription, tRNA modification, and acetylation of histones and tubulin[1][2][5][7]. ELP2 contains two WD40 domains that enable it to serve as a hub for multiple protein–protein interactions within the complex, supporting both enzymatic activity and cytoskeletal association[1][2]. ELP2 interacts with STAT3, functioning as STAT3-interacting protein 1, thereby influencing JAK-STAT signaling and contributing to regulation of cell death through NLRP3 inflammasome activation and inflammatory pyroptosis[3][6][9]. Mutations or dysfunction in ELP2 have been linked to familial dysautonomia and other disorders involving inflammatory modulation and neurodegeneration. While direct therapeutic targeting is not established, drugs affecting the JAK/STAT or NLRP3 pathways may alter processes regulated by ELP2.

Other names

Elongator complex protein 2STATIP1StIP1FLJ10879StIPSHINC-2STAT3-interacting protein 1MRT58ENSG00000134759 (gene symbol)

No drugs directly targeting ELP2; indirect mechanisms include: Inhibition of JAK/STAT pathway impacts ELP2-related functions; Blockade of NLRP3-inflammasome pathway downstream of ELP2-mediated activation.