Elongator acetyltransferase complex subunit 4 (ELP4)

Elongator acetyltransferase complex subunit 4 (ELP4) is a key component of the six-subunit Elongator complex, a histone acetyltransferase complex evolutionarily conserved in eukaryotes[1][3][5]. ELP4 contributes to multiple cellular functions, including histone acetylation and tRNA modification, which are important for transcriptional elongation and mRNA decoding[1][3][4][5][8]. ELP4 links together other subunits of the Elongator complex, facilitating stability and enzymatic activity. Dysfunction of ELP4, such as through genetic polymorphisms or deletions, has been implicated in several neurodevelopmental disorders (particularly Rolandic epilepsy, language delays, and autism), as well as certain ocular malformations through disruption of the adjacent PAX6 regulatory landscape[1]. There are no known direct drug interactions or common use as a therapeutic target; its primary interest is in disease genetics and rare neurodevelopmental syndromes[1][5][8].

Other names

Elongator complex protein 4Elongation protein 4 homologC11orf19PAXNEBPAX6 neighbor gene proteinANAN2dJ68P15A.1hELP4PAX6NEBHELP4DJ68P15A.1