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Elongator acetyltransferase complex subunit 5 (ELP5)
- Target
- ELP5
- Molecular classification
- Other, Component of multiprotein complex (Elongator complex)
01
Overview
Elongator acetyltransferase complex subunit 5 (ELP5) is a protein component of the Elongator complex, which is conserved from yeast to humans and is involved in multiple cellular processes including transcription regulation, histone acetylation, tRNA modification, and cell migration. The Elongator complex consists of six core subunits (Elp1–Elp6), where Elp4, Elp5, and Elp6 form a hexameric subcomplex important for tRNA binding and histone acetyltransferase activity. ELP5 itself is not catalytically active but is required for the structural integrity and activity of the Elongator holocomplex, influencing histone and tRNA modification. The gene is widely expressed and associated with neurodevelopmental functions; defects in the complex are implicated in certain neuropathies. ELP5 is not a known direct therapeutic target, and there are no identified interacting drugs or mechanisms of drug action specific to this subunit.
- Other names
- C17orf81DERP6HSPC002MSTP071MST071Dermal papilla-derived protein 6S-phase 2 proteinELP5
02
Biological functions
Transcription regulationChromatin remodelingtRNA modificationCell migration
03
Disease associations
Neuropathy (including hereditary sensory and autonomic neuropathy)Neurodevelopmental disordersOther (defects in Elongator complex have disease associations, primarily Elp1/Elp3)
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