Elongin A3 family member B pseudogene (ELOA3BP)

Elongin A3 family member B pseudogene (ELOA3BP, ELOA3P) is a non-coding pseudogene associated structurally with the Elongin A3 gene cluster, a group of primate-specific retrogenes encoding transcription elongation factors related to Elongin A. Unlike the functional ELOA3 protein, which acts as a promoter-associated pause-release factor regulating RNA polymerase II elongation, ELOA3BP does **not encode a functional protein** and is not considered a therapeutic target or direct disease gene. The region is referenced in genomic association studies for certain diseases, but there is no evidence for direct causality or pharmacological relevance. Multiple aliases mix functional and non-functional members of the gene family, but for ELOA3BP itself, the correct designation is as a pseudogene without biological or medical activity[1][3].

Other names

HsT828ELOA3ELOA3BELOA3CPELOA3L1EloA3CElongin-A3TCEB3CTCEB3CLTCEB3L2eloA3-like-1Putative elongin-A3 member CRNA polymerase II transcription factor SIII subunit A3RNA polymerase II transcription factor SIII subunit A3-like-1Transcription elongation factor B polypeptide 3Celongin A3 like 1elongin-A3 member Btranscription elongation factor B polypeptide 3C-like-1transcription elongation factor B subunit 3C like[1][3]

null — No mechanism of action applies. For the functional ELOA3 protein, it mediates promoter-associated RNA polymerase II pause release, but the pseudogene does not encode a protein[3].