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Target intelligence / Profile preview
Embryonic Ectoderm Development Protein (None)
- Target
- None
- Molecular classification
- WD40 repeat-containing protein, Scaffold protein, Histone modification, Transcription factor, PRC2 complex component
01
Overview
The Embryonic Ectoderm Development Protein (EED) is a WD40 repeat-containing protein and a core component of the Polycomb Repressive Complex 2 (PRC2). It plays a critical role in epigenetic gene silencing by binding to H3K27me3 and allosterically activating PRC2's methyltransferase activity. EED is essential for maintaining pluripotency, regulating cell differentiation, and controlling cell proliferation. Mutations in EED are associated with developmental disorders and cancer, making it a potential therapeutic target for small molecule inhibitors.
02
Mechanism of action
Allosteric inhibition of EED to disrupt PRC2 function
03
Biological functions
Epigenetic gene silencingMaintenance of pluripotencyCell differentiationRegulation of cell proliferationTranscriptional repression
04
Disease associations
CancerDevelopmental disorders (e.g., Weaver-like syndrome)
05
Safety considerations
Aberrant gene silencingOff-target effects on developmental processes
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