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Target intelligence / Profile preview
Embryonic Ectoderm Development Subunit (EED)
- Target
- EED
- Molecular classification
- Scaffold protein, WD40 repeat-containing protein, Histone modification
01
Overview
The Embryonic ectoderm development subunit (EED) is an essential scaffold protein within the Polycomb Repressive Complex 2 responsible for reading repressive chromatin marks and maintaining transcriptional silencing during development. Its disruption leads to profound developmental defects or disease states including cancer—making it an important target for therapeutic intervention using small molecule inhibitors designed specifically against its substrate-binding domain.
- Other names
- WD protein associating with integrin cytoplasmic tails 1WAIT-1
02
Mechanism of action
Disruption of PRC2 function by competitively binding at the substrate recognition site on EED
03
Biological functions
Epigenetic silencingStem cell pluripotencyNeurodevelopmentRegulation of transcriptionChromatin remodeling
04
Disease associations
Cohen-Gibson SyndromeOvergrowth syndromesCancer
05
Interacting drugs
Triazolopyrimidine derivatives
2 more in the full profile.
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