Target intelligence / Profile preview

Emotion regulation

Molecular classification
Other
01

Overview

Emotion regulation is a complex, multi-faceted process through which individuals influence which emotions they have, when they have them, and how they experience and express these emotions [1]. Biologically, it is mediated by the interaction between 'top-down' cortical regions, such as the dorsolateral and ventromedial prefrontal cortex, and 'bottom-up' subcortical structures like the amygdala and ventral striatum [2]. While deficits in emotion regulation are central to various psychiatric conditions including depression, anxiety, and personality disorders, the term refers to a broad physiological and psychological phenomenon rather than a discrete molecular entity such as a receptor or enzyme [3]. Consequently, 'emotion regulation' is not a therapeutic target in the pharmacological sense; instead, drugs are designed to target specific receptors (e.g., serotonin, GABA, or glutamate receptors) that modulate the neural circuits responsible for this process [1][4]. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204924/ [2] https://pubmed.ncbi.nlm.nih.gov/22180527/ [3] https://www.ncbi.nlm.nih.gov/books/NBK513280/ [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134461/

Other names
Affect regulationEmotional self-regulationEmotional control
02

Mechanism of action

Not applicable; emotion regulation is a physiological and psychological process, not a molecular target.

03

Biological functions

Cognitive controlSocial behaviorExecutive functionStress responseAffective processing
04

Disease associations

Major depressive disorderGeneralized anxiety disorderBorderline personality disorderPost-traumatic stress disorderBipolar disorderSubstance use disorder
05

Safety considerations

Lack of molecular specificityPotential for emotional bluntingSystemic side effects from modulating underlying neurotransmitter systems
06

Biomarkers

Amygdala BOLD response (fMRI)Prefrontal cortex activation (fMRI)Heart rate variability (HRV)Skin conductance responseLate positive potential (LPP) on EEG

Beyond the preview

Go deeper on Emotion regulation.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Full profile access

Explore the programs pursuing this target and their development progress.

  • Drug candidates
  • Developers
  • Development stage

Clinical trials

Full profile access

Follow the clinical studies evaluating therapies directed at this target.

  • Trial design
  • Status
  • Readouts

Competitive landscape

Full profile access

Compare approaches across drug candidates, modalities, and indications.

  • Programs
  • Modalities
  • Indications

Literature & evidence

Full profile access

Investigate the research and source evidence behind target biology and development.

  • Publications
  • Sources
  • Analysis

Patents

Full profile access

Explore patent activity around therapies and technologies addressing this target.

  • Patents
  • Assignees
  • Technologies

Research & analysis

Full profile access

Connect target biology, drug development, and emerging evidence in your research.

  • Biology
  • Development news
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on Emotion regulation.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call