Target intelligence / Profile preview

Tooth enamel (hydroxyapatite) (HA)

Target: HA
Molecular classification: Mineral, Structural protein

Overview

Tooth enamel is the hard, outer layer of teeth, composed primarily of hydroxyapatite, a crystalline calcium phosphate. It protects the underlying dentin and pulp from damage and decay. While exceptionally hard, enamel is susceptible to demineralization by acids, leading to dental caries. Fluoride can promote remineralization and enhance enamel's resistance to acid attack.

Other names: EnamelHydroxyapatiteCalcium phosphate

Mechanism of action

Fluoride promotes remineralization and forms fluorapatite, which is more acid-resistant.

Biological functions

Protection of teethStructural support

Disease associations

Dental cariesEnamel hypoplasiaEnamel erosion

Safety considerations

Acid erosionDemineralization

Interacting drugs

Fluoride

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